Table 2 Cox Proportional Hazard Model for Relationship of Cumulative Social Determinant of Health Score on Mortality
| Unadjusted | Adjusted for Demographics | Adjusted for Demographics and Lifestyle | Adjusted for Demographics, Lifestyle, Glycemic Control and Comorbidities | |||||
|---|---|---|---|---|---|---|---|---|
| Hazard Ratio (95% CI) | P- Value | Hazard Ratio (95% CI) | P- Value | Hazard Ratio (95% CI) | P- Value | Hazard Ratio (95% CI) | P- Value | |
| SDOH cumulative score | 1.11 (0.97–1.28) | 0.13 | a1.41 (1.18–1.67) | < 0.01 | a1.39 (1.18–1.64) | < 0.01 | a1.41 (1.18–1.68) | < 0.01 |
|
Gender Female (ref Male) | a0.69 (0.51–0.94) | 0.02 | a0.61 (0.45–0.84) | < 0.01 | a0.65 (0.46–0.91) | 0.01 | ||
|
Age at Screening (Increase 1 year) | a1.06 (1.05–1.07) | < 0.01 | a1.06 (1.04–1.07) | < 0.01 | a1.05 (1.04–1.06) | < 0.01 | ||
| Race (ref non-Hispanic White) | 0.03 | 0.02 | 0.03 | |||||
| non-Hispanic Black | 0.84 (0.61–1.14) | 0.83 (0.61–1.12) | 0.82 (0.60–1.11) | |||||
| Other | a0.66 (0.48–0.90) | a0.64 (0.47–0.88) | a0.65 (0.48–0.90) | |||||
|
Education level (Increase 1 level) | 0.93 (0.84–1.02) | 0.13 | 0.97 (0.88–1.08) | 0.60 | 1.00 (0.90–1.10) | 0.93 | ||
|
Insurance coverage No (ref Yes) | 0.67 (0.32–1.42) | 0.29 | 0.74 (0.34–1.57) | 0.42 | 0.69 (0.31–1.53) | 0.36 | ||
| Lifestyle Factors | ||||||||
|
Physical activity Moderate to Vigorous (ref none) | a0.51 (0.38–0.69) | < 0.01 | a0.52 (0.37–0.73) | < 0.01 | ||||
|
Smoking status Former or Current Smoker (ref none) | a1.38 (1.08–1.76) | < 0.01 | a1.35 (1.05–1.74) | 0.02 | ||||
|
Drinking status Moderate or above Drinker (ref none) | a0.61 (0.45–0.82) | < 0.01 | a0.59 (0.43–0.82) | < 0.01 | ||||
| Glycemic Control | ||||||||
| Hemoglobin A1c (%) (Increase 1%) | a1.09 (1.01–1.18) | 0.03 | ||||||
| Comorbidity | ||||||||
| Hypertension (Ref No Hypertension) | 1.00 (0.71–1.42) | 1.00 | ||||||
| Heart disease (Ref No Heart Disease) | a1.75 (1.35–2.32) | < 0.01 | ||||||
| Stroke (Ref No Stroke) | 0.99 (0.64–1.54) | 0.96 | ||||||
| Cancer (Ref No Cancer) | a1.45 (1.03–2.02) | 0.03 | ||||||