Table 3 Cox Proportional Hazard Model for Relationship of Dichotomous Social Determinant of Health Score on Mortality
| Unadjusted | Adjusted for Demographics | Adjusted for Demographics and Lifestyle | Adjusted for Demographics, Lifestyle, Glycemic Control and Comorbidities | |||||
|---|---|---|---|---|---|---|---|---|
| Hazard Ratio (95% CI) | P- Value | Hazard Ratio (95% CI) | P- Value | Hazard Ratio (95% CI) | P- Value | Hazard Ratio (95% CI) | P- Value | |
| Dichotomous SDOH score group | 0.19 | 0.01 | 0.02 | 0.01 | ||||
|
No adverse SDOH factors (0) | Ref | Ref | Ref | Ref | ||||
|
Adverse SDOH factors (≥1) | 1.19 (0.91–1.56) | a1.42 (1.07–1.88) | a1.38 (1.05–1.80) | a1.41 (1.08–1.84) | ||||
|
Gender Female (ref Male) | a0.72 (0.53–0.97) | 0.03 | 0.64 (0.47–0.88) | < 0.01 | a0.67 (0.48–0.93) | 0.02 | ||
|
Age at Screening (Increase 1 year) | a1.06 (1.04–1.07) | < 0.01 | a1.05 (1.04–1.06) | < 0.01 | a1.05 (1.03–1.06) | < 0.01 | ||
| Race (ref non-Hispanic White) | 0.07 | 0.06 | 0.08 | |||||
| non-Hispanic Black | 0.85 (0.62–1.16) | 0.85 (0.62–1.15) | 0.84 (0.61–1.16) | |||||
| Other | a0.69 (0.50–0.94) | a0.68 (0.49–0.93) | a0.69 (0.50–0.95) | |||||
|
Education level (Increase 1 level) | 0.90 (0.82–1.00) | 0.04 | 0.95 (0.86–1.05) | 0.31 | 0.97 (0.88–1.07) | 0.57 | ||
|
Insurance coverage No (ref Yes) | 0.71 (0.34–1.49) | 0.36 | 0.78 (0.37–1.66) | 0.52 | 0.75 (0.35–1.62) | 0.46 | ||
| Lifestyle Factors | ||||||||
|
Physical activity Moderate to Vigorous (ref none) | a0.51 (0.38–0.69) | < 0.01 | a0.52 (0.37–0.73) | < 0.01 | ||||
|
Smoking status Former or Current Smoker | a1.40 (1.10–1.80) | < 0.01 | a1.37 (1.05–1.79) | 0.02 | ||||
|
Drinking status Moderate or above drinker (ref none) | a0.62 (0.46–0.83) | < 0.01 | a0.59 (0.43–0.82) | < 0.01 | ||||
| Glycemic Control | ||||||||
| Hemoglobin A1c (%) (Increase 1%) | a1.10 (1.01–1.19) | 0.02 | ||||||
| Comorbidity | ||||||||
| Hypertension (Ref No Hypertension) | 1.02 (0.73–1.44) | 0.90 | ||||||
| Heart disease (Ref No Heart Disease) | a1.80 (1.37–2.37) | < 0.01 | ||||||
| Stroke (Ref No Stroke) | 0.97 (0.62–1.53) | 0.91 | ||||||
| Cancer (Ref No Cancer) | a1.41 (1.00–1.99) | 0.05 | ||||||